Table 2.

Comparative performance of biomarkers for children who died up to 7 days or who survived in derivation, primary and secondary validation cohort.

Biomarker	Derivation (n = 1,176)		Primary validation (n = 1,176)		Secondary validation (n = 908)
	AUROC (95% CI)	P-value	AUROC (95% CI)	P-value	AUROC (95% CI)	P-value
sTREM-1	0.893 (0.843 to 0.944)	–	0.894 (0.844 to 0.944)	–	0.901 (0.856 to 0.947)	–
sFIt1	0.859 (0.792 to 0.926)	0.103	0.860 (0.792 to 0.927)	0.102	0.796 (0.728 to 0.864)	≤0.001
IL-8	0.843 (0.772 to 0.914)	0.105	0.845 (0.775 to 0.916)	0.115	0.790 (0.712 to 0.868)	≤0.001
Ang-2	0.846 (0.787 to 0.905)	0.081	0.847 (0.789 to 0.904)	0.084	0.784 (0.715 to 0.853)	≤0.001
CHI3L1	0.826 (0.750 to 0.902)	0.054	0.829 (0.754 to 0.904)	0.064	0.771 (0.702 to 0.840)	≤0.001
sTNFR1	0.783 (0.696 to 0.870)	≤0.001	0.785 (0.702 to 0.868)	≤0.001	0.803 (0.726 to 0.879)	0.002
IL-6	0.821 (0.743 to 0.900)	0.064	0.824 (0.749 to 0.899)	0.065	0.753 (0.673 to 0.832)	≤0.001
sICAM-1	0.663 (0.561 to 0.764)	≤0.001	0.666 (0.566 to 0.765)	≤0.001	0.620 (0.535 to 0.704)	≤0.001
sVCAM-1	0.660 (0.561 to 0.759)	≤0.001	0.662 (0.560 to 0.763)	≤0.001	0.608 (0.534 to 0.682)	≤0.001
IP-10	0.581 (0.486 to 0.677)	≤0.001	0.583 (0.489 to 0.677)	≤0.001	0.566 (0.484 to 0.648)	≤0.001
Ang-1	0.347 (0.261 to 0.433)	≤0.001	0.350 (0.261 to 0.439)	≤0.001	0.331 (0.262 to 0.401)	≤0.001

P-values correspond to difference in AUROC as compared to AUROC of sTREM-1 and were derived from Chi-squared tests. Primary validation was based on 500 bootstrap samples with replacement in the derivation cohort. Secondary validation was performed in the temporally defined validation cohort.

AUROC area under the receiver operating characteristic curve, CI confidence interval.