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. 2021 Nov 26;6:402. doi: 10.1038/s41392-021-00791-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Structure and phosphorylation sites of the STAT protein family. The signal transduction and activator of transcription (STAT) family have six members: STAT1 (STAT1 has two splicing isoforms, STAT1α and STAT1β), STAT2, STAT3 (STAT3 has two splicing isoforms, STAT3α and STAT3β), STAT4, STAT5a, STAT5b, and STAT6. STATs are composed of 750–900 amino acids. From the N-terminus to the C-terminus, the domains are the nitrogen-terminal domain, coiled-coil domain, DNA-binding domain, junction domain, SH2 domain, and transcription-activation structure. "Y" represents a tyrosine phosphorylation site, and "S" represents a serine phosphorylation site. Created with BioRender.com