Variables	Meaning
V	cell volume
M	totle protein mass
V c	cytoplasmic volume
V n	nuclear volume
ρ	protein mass per cell volume
a	ratio between cell volume and nuclear volume
k n,i	mRNA production rate of gene i
Γn,i	transcriptional initiation rate of gene i
g i	gene copy number of gene i
P b,i	RNAPs binding probability on the promoter of gene i
c n,free	free RNAPs concentration
F n	free RNAPs fraction
Λn,i	maximum number of RNAPs one copy of gene i can hold
n c	maximum number of RNAPs the entire genome can hold
L i	length of gene i
v n	RNAP elongation speed
K n,i	transcriptional MM constant of gene i
〈Kn,i〉	weighted average of MM constant
n	RNAPs number
τ m,i	lifetime of mRNA i
m i	mRNA number of gene i
k r,i	protein production rate of gene i
Γr,i	translational initiation rate of gene i
c r	ribosomes concentration
F r	free ribosomes fraction
K r,i	translational MM constant of gene i
τ p,i	lifetime of protein i
p i	protein number of gene i
β i	nonlinear degree of mRNA i
α i	nonlinear degree of protein i
ϕ n	RNAPs mass fraction
ϕ r	ribosomes mass fraction