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. 2021 Nov 25;11:22958. doi: 10.1038/s41598-021-02489-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differential regulation of ISGs between severe and mild Symptomatic COVID-19 cases. Volcano plot of Symptomatic ‘Severe’ vs ‘Mild’ COVID-19 cases. The log2 (FC) (fold change) is plotted on the x-axis, and the negative log10 (FDR) (p-value) is plotted on the y-axis. The red points on the plot show Upregulated expression (n = 53 genes), Downregulated genes (n = 183) are shown in green. Analysis with the absolute value of log2 (FC) not less than 1 (FC = 2) and FDR values less than 0.05. Genes which have a p < 0.05 ANOVA with Benjamini–Hochberg FDR are illustrated. Selected highly differentially regulated genes are labelled.