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. 2021 Nov 25;11:22913. doi: 10.1038/s41598-021-02119-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptional regulation of p65 iso5 on human IL-6-luc and TNFα-luc promoters. (a) Effect of p65 iso5 on natural human promoter IL-6-luc. HeLa cells were cotransfected with a luciferase reporter driven by promoter IL6-651luc; IL6-651luc mut κB; IL6-651luc mut GRE; IL-6-651luc mut AP-1; IL-6-651luc mut CRE; IL-6-651luc mut c/EBP and the plasmids p50, p65 and p65 iso5. (b) HeLa cells were cotransfected with a luciferase reporter driven by promoter TNFα-luc and the indicated plasmids. Cells were maintained in RPMI 1640 supplemented with Charcoal–dextran (CD) Fetal Bovine Serum (FBS). Data information: in (a, b), data are presented as mean ± SEM. *P < 0.001, in comparison to cells transfected with reporter plasmid.