Table 1.

Overview of the main functionalities of the NeDRex platform.

Functionality	Description
Integrating data from multiple biomedical databases	NeDRexDB is an integrated knowledgebase which is accessible via NeDRexAPI as well as a Neo4j endpoint.
Constructing heterogeneous biological networks from NeDRexDB	Based on users’ needs, different heterogeneous networks can be constructed using NeDRexAPI or NeDRexApp.
Disease module mining	Various disease module identification algorithms can be run on NeDRexDB using NeDRexApp or NeDRexAPI, based on users’ inputs.
Drug prioritization	Various drug prioritization algorithms can be run on NeDRexDB using NeDRexApp or NeDRexAPI, based on users’ inputs and the results of disease module mining.
Statistical validation of results	The results of disease module identification and drug prioritization analyses can be validated with different statistical methods.
Visualization of results	Using NeDRexApp, all the obtained results are shown in network format, which can be explored further.