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. 2021 Nov 19;15(2):dmm048953. doi: 10.1242/dmm.048953

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© 2021. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Drosophila KRAS^G12V genetic screen and the hits that rescue the hemocyte overproliferation and developmental lethality phenotypes. (A) Schematic illustration of the approach used for the genetic screen (see Materials and Methods section for a detailed description of rationale, strategy and procedure). (B) The 24 Drosophila genes that, when silenced in hemocytes, completely rescued KRAS^G12V-induced hemocyte overproliferation and developmental lethality phenotypes. Also listed are the human homologs of these genes, their DIOPT score (indicating the degree of conservedness) and the predicted function of the proteins encoded by these genes.