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The Ω-loop pocket seen in TEM may open in other β-lactamase homologs. The structures of four β-lactamase homologs (Left) overlay well. TEM (Protein Data Base [PDB]: 1xpb) is shown in green, CTX-M-9 (PDB: 1ylj) is shown in cyan, MTB (PDB: 2gdn) is shown in orange, and GNCA (PDB: 4b88) is shown in magenta. The open Ω-loop pocket structure in TEM (Right) was identified in molecular dynamics simulations.
