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Animal Models to Generate Neointmal Hyperplasia
Angioplasty and other vascularization procure cause a trauma to the vessel wall leading to neointimal hyperplasia via 4 major mechanisms: (1) Endothelial injury and platelet aggregation; (2) Endothelial dysfunction and leukocyte adhesion; (3) smooth muscle cell migration and proliferation; (4) Formation of the neointima. LDL = low-density lipoprotein; VSMC = vascular smooth muscle cell.
