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. 2021 Nov 16;23(1):21. doi: 10.3892/ol.2021.13139

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Copyright: © Xiong et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Targets of SRSF3. SRSF3 is involved in the splicing of numerous hub genes, including CD44, HER2, MDM4, RAC1 and TP53. Therefore, SRSF3 plays important roles in the regulation of cell proliferation, cell cycle, apoptosis and proliferation. SRSF3, serine/arginine rich splicing factor 3; MDM, mouse double minute; RAC1, Rac family small GTPase 1; TP53, tumor protein p53; RTK, receptor tyrosine kinases; IRS, insulin receptor substrate; PIP₃, phosphatidylinositol (3,4,5)-trisphosphate; PIP₂, phosphatidylinositol 4,5-bisphosphate; CCND1, cyclin D1; PDCD4, programmed cell death 4; PDK1, pyruvate dehydrogenasekKinase 1; PKM, pyruvate kinase M; HIF1A, hypoxia inducible factor 1 subunit α; P, phosphate.