Figure 2.

Regulators, targets and splicing events of SRSF3. Hypoxia, HNRNPL and trichostatin induce SRSF3 expression, while caffeine, theophylline and digoxin inhibit SRSF3 expression. The splicing of SRSF3 is regulated by SRSF3 itself, amiodarone, sodium arsenite and cir87MARCA5 by including exon, and also regulated by HNRNPL, PTBP1, PTBP2 and SLU7 through exon skipping. SRSF3 regulates splicing of multiple genes in different ways such as including exon, skipping exon and including intron. SRSF3, serine/arginine rich splicing factor 3; HNRNPL, heterogeneous nuclear ribonucleoprotein L; PTBP, polypyrimidine tract binding protein; SLU7, SLU7 homolog.