Table I.
Regulators, targets and splicing events of SRSF3.
Regulator | Target | Splicing event | Isoform | Cell line | (Refs.) |
---|---|---|---|---|---|
HNRNPL | SRSF3 | Skipping of exon 4 | SRSF3-FL | CAL 27 | (23) |
PTBP1 and PTBP2 | OSCC | (46) | |||
SLU7 | PLC, H358, and HeLa | (47) | |||
SRSF3 | SRSF3 | Inclusion of exon 4 | SRSF3-TR | K46 | (43–45) |
Amiodarone | HeLa | (49) | |||
Sodium arsenite | HCT116 | (50) | |||
circ87MARCA5 | U87MG | (51) | |||
SRSF3 | CDCA5 | Retention of intron 1 and2 | NA | PLC | (47) |
EIF2B5 | Retention of intron 12 | EIF2B5-TR | SQ20B | (16) | |
PDCD4 | Retention of intron 2 | Isoform2 | SW480 | (29) | |
CD44 | Splicing of exons 8, 9, and 10 | CD44E | HEK293 | (32,59) | |
G6PD | Inclusion of exon 12 | G6PD-FL | HepG2 | (54) | |
GR | Inclusion of exon 9a | GRα | MDA-MB-231 | (74,75) | |
KLF6 | Inclusion of exon 3 | KLF6-FL | Hep3B, Huh7, and HepG2 | (22) | |
MAP4K4 | Inclusion of exon 16 | Isoform2 and 5 | HCT-8 | (73) | |
MDM4 | Inclusion of exon 6 | MDM4-FL | A375 | (67) | |
NUMB | Inclusion of exon 12 | NUMB-FL | MDA-MB-231 | (76) | |
PKM | Inclusion of exon 10 | PKM2 | DLD-1 and WiDr | (61) | |
CASP2 | Skipping of exon 9 | Casp-2L | HeLa and MDA-MB-231 | (107) | |
CLK1 | Skipping of exon 4 | CLK1-TR | WI-38 | (40) | |
FoxM1 | Skipping of exon 9 and/or 6 | Isoform b and c | U2OS and HeLa | (24) | |
HER2 | Skipping of exon 16 | Δ16HER2 | SKBR3 | (108) | |
ELP1 | Skipping of exon 20 | ELP1-TR | HEK293 | (40) | |
ILF3 | Skipping of exon 18 or 18b | Isoform1 and2 | WI-38 | (66) | |
KMT2C | Skipping of exon 46a | KMT2C-S | A2780 | (68) | |
PDK1 | Skipping of exon 3a | PDK1-TR | HEK293 | (40) | |
RAC1 | Skipping of exon 3b | RAC1b | HT29 | (33) | |
SMN2 | Skipping of exon 7 | SMN2-TR | HeLa | (83) | |
MAPT | Skipping of exon 10 | MAPT-TR | SKN-MC and C33A | (84) | |
TP53 | Skipping of exon 9i | p53β | MRC-5 | (25) | |
TP53I3 | Skipping of exon 4 | TP53I3-TR | HEK293 | (40) |
SRSF3, serine/arginine rich splicing factor 3; NA, not applicable.