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. 2021 Nov 18;2021:3501770. doi: 10.1155/2021/3501770

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Copyright © 2021 Chang Yeon Kim et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Neurotrophin signaling pathway and corresponding DEPs. “Neurotrophin signaling pathway” within the overall “full” KEGG pathway. DEP: differentially expressed protein; NGF: nerve growth factor; BDNF: brain-derived neurotrophic factor; NT3,4: neurotrophin 3,4; TrkA/B/C: neurotrophic receptor tyrosine kinase 1, 2, and 3; ARMS: ankyrin repeat-rich membrane-spanning protein; FRS2: fibroblast growth factor receptor substrate 2; CREB: CAMP-responsive element-binding protein; GRB2: growth factor receptor-bound protein 2; SOS: Son of Sevenless; Mapk14: mitogen-activated protein kinase 14; MK-2: mitogen-activated protein kinase-activated protein kinase 2; Gab1: GRB2-associated binding protein 1; PI3K: phosphoinositide-3-kinase; PIP3: phosphatidylinositol-3,4,5-trisphosphate; PDK: 3-phosphoinositide-dependent protein kinase-1; Bad: BCL2-associated agonist of cell death; GSK3β: glycogen synthase kinase 3 beta; FasL: Fas ligand.