Table 1.
Hemodynamic Variables and Extravascular Lung Water Content Following Induction of Chronic Ischemic Heart Failure
| Heart Failure (n = 7) | Healthy (n = 7) | P Value | |
|---|---|---|---|
| HR, beats/min | 67 ± 2 | 117 ± 6 | <0.001 |
| MSP, mm Hg | 81 ± 5 | 79 ± 9 | 0.862 |
| CVP, mm Hga | 5.8 ± 0.4 | 2.2 ± 0.9 | 0.004 |
| EDP, mm Hgb | 16.4 ± 1.4 | 3.9 ± 1.4 | <0.001 |
| +dP/dt40, mm Hg/sb | 1,183 ± 5 | 1,684 ± 118 | 0.001 |
| -dP/dt40, mm Hg/sb | -759 ± 67 | -1,320 ± 160 | 0.007 |
| Contractility index, 1/sb | 29.6 ± 0.1 | 42.1 ± 2.9 | 0.001 |
| LV-tau, msb | 25.5 ± 3.6 | 16.6 ± 1.8 | <0.05 |
| EVLW, mLc | 202 ± 20 | 31 (n = 1) | — |
Values are mean ± SEM; healthy animal data taken from both historical controls (n = 6) and 1 healthy animal studied under this protocol.
CVP = central venous pressure; dP/dt40 = the first derivative of the left ventricular pressure signal at a developed left ventricular pressure of 40 mm Hg; EDP = end-diastolic pressure; EVLW = extravascular lung water HR = heart rate; LV-Tau = left ventricular–tau; MSP = mean systolic pressure.
Derived/estimated from the mean right-atrial pressure.
Derived/estimated from the left-ventricular pressure signal, where contractility index = +dP/dt40/40 mm Hg.
Derived/measured via dual-indicator thermodilution (5 mL of either cold 0.9% NaCl or cold 6% hetastarch solutions) using a right-sided Swan-Ganz catheter advanced into the pulmonary artery trunk, and a thermistor catheter advanced into the aortic arch.