Table 3.
Changes in Hemodynamics, Extravascular Lung Water Content, and in Treated and Control Animals
| ADHF Treatment Group (n = 4) |
ADHF Control Group (n = 3) |
|||||
|---|---|---|---|---|---|---|
| ADHF | ADHF + Treatment | P < 0.05a | ADHF | ADHF + Control | P < 0.05a | |
| HR, beats/min | 73 ± 9 | 94 ± 6 | — | 86 ± 19 | 111 ± 4 | — |
| MSP, mm Hg | 142 ± 8 | 116 ± 17 | — | 153 ± 15 | 117 ± 10 | 0.026 (↓) |
| CVP, mm Hgb | 11.8 ± 0.8 | 10.7 ± 1.0 | — | 12.4 ± 1.9 | 15.0 ± 4.7 | — |
| EDP, mm Hgc | 34.7 ± 0.2 | 24.5 ± 3.0 | 0.038 (↓) | 30.2 ± 2.3 | 27.5 ± 7.6 | — |
| +dP/dt40, mm Hg/sc | 1,044 ± 117 | 1,452 ± 301 | — | 1,213 ± 137 | 1,306 ± 40 | — |
| -dP/dt40, mm Hg/sc | -800 ± 124 | -724 ± 108 | — | -1,121 ± 176 | -773 ± 44 | — |
| Contractility index, 1/sc | 26.1 ± 2.9 | 36.3 ± 7.5 | — | 30.3 ± 3.4 | 21.8 ± 10.9 | — |
| EVLW, mLd | 512 ± 45 | 358 ± 58 | 0.038 (↓) | 326 ± 18 | 471 ± 14 | — |
| EVLW, mL/kgd | 8.7 ± 0.6 | 6.2 ± 1.1 | 0.029 (↓) | 7.2 ± 1.6 | 10.2 ± 1.5 | 0.003 (↑) |
| IVLW, mLd | 476 ± 87 | 396 ± 64 | — | 417 ± 80 | 446 ± 109 | — |
| PaO2, mm Hg | 408 ± 27 | 273 ± 68 | — | 325 ± 88 | 101 ± 48 | — |
| Cardiac output, L/mind | 11.8 ± 1.2 | 10.2 ± 1.5 | 0.034 (↓) | 11.1 ± 1.9 | 8.1 ± 0.5 | — |
| Urine output, mL, %inpute | 1,169 ± 419 (22 ± 6) | 1,932 ± 417 (33 ± 5) | 0.043 (↑) | 729 ± 243 (22 ± 7) | 1,132 ± 193 (23 ± 4) | — |
| Plasma hemoglobin, g/L | 0.48 ± 0.11 | 0.63 ± 0.20 | — | 0.80 ± 0.20 | 1.10 ± 0.15 | — |
Values are mean ± SEM; ADHF induced via the overlapping combination of both fluid and pressure overload; data are reported after 94.3 ± 4.3 min of overload.
Versus ADHF, reflecting either an increase (↑) or decrease (↓).
Derived/estimated from the mean right-atrial pressure (RAP).
Derived/estimated from the left-ventricular pressure signal, where CI = +dP/dt40/40 mmHg.
Derived/measured via dual-indicator thermo-dilution (5 mL of either cold 0.9% NaCl or cold 6% hetastarch solutions) using a right-sided Swan-Ganz catheter advanced into the pulmonary-artery trunk, and a thermistor catheter advanced into the aortic arch.
Total urine output as recorded during ADHF induction, and during the treatment period, with the percentages of the respective total fluid input shown in parenthesis.