TABLE 3.
Age (yr), gender (reference) | Clinical diagnosis or signs | Cat contact | Origin of tissue sample | gltA sequence | 16S rRNA type | Bh ftsZ variant | Date of serum sample (mo/day/yr) | Antibody titer
|
Treatment | Outcome | ||
---|---|---|---|---|---|---|---|---|---|---|---|---|
B.h. | B.e. | B.q. | ||||||||||
37, M (33) | ARVC, autopsy finding | Former cat owner | Myocardium from right ventricle wallb | B.h. | ND | 1 | 1/5/99 | <64 | <64 | <64 | ||
32, M (33) | ARVC (endomyocardial biopsy; presence of late potentials) | Former cat owner | Whole blood | Neg | ND | 2 | 1993 | 256 | 256 | <64 | Tetracycline, 200 mg daily, was started | |
1/98 | 256 | 256 | <64 | |||||||||
6/10/98 | <64 | 128 | <64 | |||||||||
02/17/99 | <64 | <64 | <64 | |||||||||
8, M | Chronic multifocal osteomyelitis | Cat scratch 4 mo before onset of symptoms | Bone biopsy specimen from the left sternoclavicular joint | Neg | ND | 1 | 3/20/98 | 128 | <64 | <64 | Erythromycin, 250 mg twice daily, 8 wk | Signs of recovery before treatment |
4/17/98 | 256 | <64 | <64 | |||||||||
5/19/98 | 64 | <64 | <64 | |||||||||
6/18/98 | <64 | <64 | <64 | |||||||||
12, F | Chronic multifocal osteomyelitis | Close contact with kittens 2 mo before onset of symptoms | Bone biopsy specimen from right sternoclavicular joint | B.h. | ND | 2 | 2/18/99 | <64 | <64 | <64 | Clarithromycin, 250 mg twice daily, 8 wk | Complete recovery within 4 wk |
5/10/99 | <64 | <64 | <64 | |||||||||
14, M | Lymph node hyperplasia; abdominal pain; granulocytopenia and trombocytopenia developed | Regular cat contact | Enlarged axillary lymph node | B.h. | ND | 1 | 11/13/98 | <64 | <64 | <64 | (i) T/S, 14 days; (ii) Clarithromycin, 250 mg twice daily, 8 wk | Subjective improvement, but persisting granulocytopenia and trombocytopenia |
17, F | Lymph node hyperplasia and anemia | Cat owner | Hyperplastic abdominal lymph node | Neg | ND | 2 | 08/17/98 | <64 | <64 | <64 | Excision of abdominal enlarged lymph gland | Complete recovery |
10/7/98 | <64 | <64 | <64 | |||||||||
46, F | Parinaud's oculoglandular syndrome of the cat owner | Cat owner | Cat blood | B.h. | ND | 1 | Cat owner, 1/4/99; 5/4/99; cat, 2/1/99 | <64 | <64 | Azitromycin, 500 mg on day 1, 250 mg on days 2 to 5 | Symptoms gradually resolving after 2 days | |
<64 | <64 | |||||||||||
256 | 256 |
Abbreviations: ND, not determined; B.h., B. henselae; B.q., B. quintana; B.e., B. elizabethae, T/S, trimethoprim-sulfamethoxazole; M, male; F, female; ARVC, arrhythmogenic right ventricular cardiomyopathy; neg, negative. At the time of admission all patients lived in Central Sweden.
PCR products were obtained by both PCR assays from the following tissue specimens: (i) left heart ventricle (myocardium and epicardium); (ii) right heart ventricle (superficial myocardium and epicardium); (iii) right heart ventricle (myocardium); (iv) vena cava and right atrium; (v) left atrioventricular (mitral) valve; (vi) papillary muscle adjacent to specimen 5; (vii) lymph node from the proximity of the tracheal bifurcation. Subsequent sequencing of the amplified products gave identical results.