Table 1.

Inhibition (IC₅₀ values) of dopamine and serotonin uptake by synthetic cathinones; doses of cathinones eliciting motor activation and motor sensitization in rodents.

Synthetic Cathinones	IC50 DA uptake (μM)	IC50 5-HT uptake (μM)	Motor activation (mg/kg)	Motor sensitization (mg/kg)	Reference
α-PBP	0.06331; 0.0782	> 101,2	3–101 or 2.5–2517 (mice)	N/A	1 Marusich et al., 2014
α-PPP	0.19671; 0.5402	> 101,2	10–30 (mice)1	N/A	2 Eshleman et al., 2017
α-PVP	0.01281; 0.01972; 0.01753	> 101,2	3–101 or 2.5–2517 (mice)	N/A	3 Kolanos et al., 2015a
			1–1020 (rats)		4 Simmler et al., 2013
Butylone	2.904; 0.2117; 1.716	6.224; 1.977; 0.686	5–256 or 10–305 (mice)	N/A	5 Gatch et al., 2013
Cathinone	14.04; 0.8569	> 104,9	1–48 (rats)	1–48 (rats)	6 López-Arnau et al., 2012
4-FMC	6.354; 0.2737	> 104,7	105 or 17–3010 (mice)	N/A	7 Eshleman et al., 2013
MDPV	0.00411,11; 0.01267; 0.0048512	3.3051; 3.34911; 1.387	1–3, 17 or 301,5,10,20 (mice)	0.325 (mice)	8 Shortall et al., 2013
				0.524 or 123,27 (rats)	9 Fleckenstein et al., 1999
			0.3–3 29 or 1–1019 (rats)		10 Marusich et al., 2012
Mephedrone	3.314; 0.0987; 0.9713; 0.76211	4.644; 0.5107; 0.3113; 0.42211	3–105, 5–256 or 3–3010 (mice)	3 28 (mice)	11 Baumann et al., 2014
				0.521, 224, 108 or 1526 (rats)	12 Kolanos et al., 2015b
			108 or 3–3021 (rats)		13 Martínez-Clemente et al., 2012
Methcathinone	1.124; 0.1447; 0.3449; 0.35615	> 104,7,9,15	1–3018 (mice)	N/A
Methedrone	3514	4.7314	3010 (mice)	N/A	14 Simmler et al., 2014
Methylone	4.824; 0.3437; 0.566; 2.916; 0.81915; 1.23211	15.54; 1.927; 0.236; 2.316; 5.7515; 1.01711	3, 10–305,10 or 5–256 (mice)	N/A	15 Cozzi et al., 1999
					16 Nagai et al., 2007
Naphyrone	0.474; 0.01267	0.964; 0.05937	10–1005 (mice)	N/A	17 Gatch et al., 2015a
Pentedrone	2.5014; 0.17622	> 1014; 92	2.5–2518 (mice)	N/A	18 Gatch et al., 2015b
Pentylone	1.3414; 0.1672	8.3714; 0.812	10–10018 (mice)	N/A	19 Aarde et al., 2015a
3-FMC	1.714; 0.2142	> 102,14	1, 3–3010,18 (mice)	N/A	20 Fantegrossi et al., 2013
4-MEC	4.2814; 0.962	7.9314; 0.2182	30–10019 (mice)	3022 (rats)	21 Lisek et al., 2012
			3022 (rats)		22 Xu et al., 2016
					23 Gregg et al., 2016
					24 Berquist et al., 2016
					25 Buenrostro-Jàuregui et al., 2016
					26 Gregg et al., 2013a
					27 Watterson et al., 2016
					28 Berquist et al., 2015
					29 Novellas et al., 2015
					N/A: no available data