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. 2021 Nov 5;10(11):3026. doi: 10.3390/cells10113026

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Antihistamines potentiate the dexamethasone-induced expression of endogenous anti-inflammatory genes. (A,B) A549 cells or (C,D) U937 cells were exposed for 10 min to 10 μM mepyramine (MEP), 10 μM trans-triprolidine (TRIP), 10 μM cetirizine (CET), 10 μM chlorpheniramine (CHLOR), 10 μM diphenhydramine (DIPH), or 10 μM azelastine (AZE) as indicated, and then treated with dexamethasone (DEX) for 3 h, as indicated. GILZ and MKP-1 mRNA levels were quantified by qPCR as described in the methods section. Results are mean +/− SD of at least three independent experiments performed in triplicates. Statistical significance was denoted using letters above bars. Means indicated with a common letter are not significantly different. Likewise, means not sharing any letter are significantly different.