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. 2021 Nov 5;10(11):3026. doi: 10.3390/cells10113026

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Azelastine counteracts dexamethasone-induced modulation of bone metabolism marker genes. MC3T3-E1 pre-osteoblastic cells differentiated to osteoblasts were exposed for 10 min to 10 μM azelastine (AZE) and then treated with 0.1 nM dexamethasone (DEX) for 3 h. (A,B) Receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), and (C) osteocalcin (OC) mRNA levels were quantified by qPCR as described in the methods section. Results are mean +/− SD of at least three independent experiments performed in triplicates. Statistical significance was denoted using letters above bars. Means indicated with a common letter are not significantly different. Likewise, means not sharing any letter are significantly different.