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. 2021 Nov 18;13(11):1951. doi: 10.3390/pharmaceutics13111951

Table 5.

Codelivery of photosensitizer and hyperthermia agent drugs based on nanocarriers.

Nanoparticle Photosensitizers Hyperthermia Agents Tumor Data Sources Findings Ref
Cancer cell membrane-cloaked Ce6-loaded Janus magnetic mesoporous organosilica NPs (CM@M-MON@Ce6) Chlorin e6 (Ce6) Magnetic mesoporous silica nanoparticles (M-MSNs) 4T1 In vitro, Animals
  • It exhibited the function of REDOX/PH double stimulation to induce PS release and matrix degradation.

  • Increased the ability of targeted tumor aggregation and prolonged blood circulation time.

  • Enhanced anticancer activity, simultaneously triggering a series of immunogenic cell death, resulting in a synergistic tumor-specific immune response.

[174] 2019
Ultramagnetic photosensitive liposomes Foscan Iron oxide NPs SKOV-3 In vitro, Animals
  • The combination of photodynamic and magnetothermal therapy triggered the synergistic action of apoptotic signaling pathways, leading to complete eradication of tumor cells.

[175] 2015
Magneto low-density nanoemulsion (MLDE) Chlorin e6 (Ce6) Iron oxide NPs MCF-7 In vitro
  • Improved the stability and biocompatibility of drugs.

  • Identified the low-density lipoprotein receptor on the surface of tumor cells and improved the targeting selectivity of drugs.

[176] 2018