Table 7.

Codelivery of photosensitizers and sonophotosensitizers based on nanocarriers.

Nanoparticle	Photosensitizers	Sonophotosensitizers	Tumor	Data Sources	Findings	Ref
Glypican-3-targeted, curcumin-loaded microbubbles (GPC3-CUR-MBs)	Curcumin (CUR)	Curcumin (CUR)	HepG2	In vitro, Animals	The combined therapy sonophotodynamic therapy (SPDT) had more obvious antitumor effects than SDT or PDT alone.	[213] 2020
Curcumin-loaded poly(L-lactic-co-glycolic acid) microbubbles (CUR-PLGA-MBs)	Curcumin (CUR)	Curcumin (CUR)	HepG2	In vitro	Mitochondrial membrane potential loss was induced by increased reactive oxygen species (ROS) generation, leading to tumor cell apoptosis and thermal decay.	[214] 2020
5-Aminolevulinic acid/titanium dioxide NPs (5-ALA/TiO2)	5-Aminolevulinic acid (5-ALA)	Titanium dioxide (TiO2)	SCC	In vitro, Animals	Using countercurrent chromatography to obtain regular size nanoparticles enhanced the efficacy of codelivery of PDT and SDT for tumor treatment.	[215] 2016