Figure 2.

Plasma concentration–time curves (A), plasma AUC_0–4h (B), brain concentration (C), brain-to-plasma ratio (D), testis concentration (E) and testis-to-plasma ratio (F) of selpercatinib in male wild-type, Abcb1a/1b; Abcg2^-/- and Slco1a/1b^-/-mice over 4 h after oral administration of 10 mg/kg selpercatinib. Data are given as mean ± S.D. (n = 6–7). Statistical analysis was applied after log-transformation of linear data. *, p < 0.05; **, p < 0.01; ***, p < 0.001 compared to wild-type mice. Statistical analysis was applied after log-transformation of linear data.