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In vitro uptake of selpercatinib (A) and positive control rosuvastatin (B) by human OATP1A2, OATP1B1 and OATP1B3. Uptake of 5 µM selpercatinib and 0.2 µM rosuvastatin were measured after 2.5 min incubation using vector-transfected (control) or OATP1A2-, OATP1B1- or OATP1B3- overexpressing HEK293 cells. n = 3, data are given as mean ± S.D. *, p < 0.05; **, p < 0.01; ***, p < 0.001 compared to control group.
