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Plasma concentration–time curves (A) and plasma AUC0–8h (B) of selpercatinib in female wild-type, Cyp3a-/- and Cyp3aXAV mice 8 h after oral administration of 10 mg/kg selpercatinib. Data are given as mean ± S.D. (n = 6–7). *, p < 0.05; **, p < 0.01; ***, p < 0.001 compared to wild-type mice; #, p < 0.05; ##, p < 0.01; ###, p < 0.001 compared between Cyp3a-/- and Cyp3aXAV mice. Statistical analysis was applied after log-transformation of linear data.
