Table 4.
Mediation Analysis.
| Outcome | Treatment | Mediator | Effect | Estimate | SE | 95% CI | Z | p-Value | |
|---|---|---|---|---|---|---|---|---|---|
| Lower | Upper | ||||||||
| FA (20:4) (6hr diff) |
rs174577 | cg27386326 | Total Effect | −0.24 | 0.04 | −0.32 | −0.15 | −5.39 | <0.0001 |
| Natural Direct Effect (Treatment) | −0.18 | 0.06 | −0.29 | −0.06 | −2.98 | 0.0029 | |||
| Natural Indirect Effect (Mediator) | −0.06 | 0.04 | −0.14 | 0.02 | −1.57 | 0.1173 | |||
| Percentage Mediated | 25.95 | 17.24 | −7.84 | 59.74 | 1.51 | 0.1322 | |||
| cg19610905 | Total Effect | −0.24 | 0.04 | −0.32 | −0.15 | −5.39 | <0.0001 | ||
| Natural Direct Effect (Treatment) | −0.18 | 0.05 | −0.27 | −0.09 | −3.83 | 0.0001 | |||
| Natural Indirect Effect (Mediator) | −0.06 | 0.02 | −0.09 | −0.02 | −3.18 | 0.0015 | |||
| Percentage Mediated | 24.17 | 8.69 | 7.15 | 41.20 | 2.78 | 0.0054 | |||
| rs174547 | cg07689907 | Total Effect | −0.24 | 0.04 | −0.32 | −0.15 | −5.36 | <0.0001 | |
| Natural Direct Effect (Treatment) | −0.22 | 0.05 | −0.31 | −0.12 | −4.50 | <0.0001 | |||
| Natural Indirect Effect (Mediator) | −0.02 | 0.02 | −0.06 | 0.02 | −0.96 | 0.3394 | |||
| Percentage Mediated | 7.99 | 8.49 | −8.65 | 24.62 | 0.94 | 0.3468 | |||
Abbreviations: FA (20:4)-arachidonic acid; SE-standard error; CI-confidence interval.