Table 1.
Cytotoxicity of RuBIS CPNs and complex 2 in A431 and A549 cancer cell lines in the dark and under green light (λexc = 520 nm, 39.3 J/cm2) irradiation.
| Cell Type | Light DoseJ/cm2 | RuBIS CPNs | Complex 2 | Cisplatin | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| EC50 (µM) | CI [a] | PI [b] | EC50(µM) | CI [a] | PI [b] | EC50(µM) | CI [a] | PI [b] | ||
| A431 | 0 | 11.9 | +0.46 −n.a. |
2.4 | 28.1 | +0.06 −0.60 |
1.7 | 3.0 | +0.45 −0.41 |
1.1 |
| 39.3 | 5.0 | +0.04 −0.04 |
16.3 | +0.55 −0.32 |
3.3 | +0.31 −0.28 |
||||
| A549 | 0 | 9.1 | +0.09 −0.08 |
1.8 | 28.3 | +1.16 −0.74 |
1.0 | 3.0 | +0.15 −0.15 |
1.0 |
| 39.3 | 5.0 | +0.02 −0.02 |
27.5 | +0.43 −0.37 |
3.0 | +0.17 −0.17 |
||||
[a] Confidence interval, [b] photo indices. EC50 values are expressed in μM as half-maximal effective concentration (95% confidence interval are also given in μM).