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. 2021 Oct 29;10(11):1401. doi: 10.3390/pathogens10111401

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparison of Schistosoma mansoni-derived EVs and Fasciola hepatica-secreted EVs lectin microarray profiles. (A) Heat map and two-dimensional hierarchical clustering of scale-normalised lectin microarray profile data for all twelve SmEV technical replicates, 4 from one EV isolation sample (SmEV1 A-D) and 8 from pooled EV samples (SmEVc A-H), and three FhEV replicates (Fh 120k EV A-C) obtained by de la Torre-Escudero et al. (2019). Data depicted in heat map was scaled to fit a 0–30,000 RFU window and clustered by average linkage, Euclidean distance method (B) Regression analysis comparing S. mansoni EV and F. hepatica EV lectin-binding profiles.