GIP |
glucose-dependent insulinotropic polypeptide (previously known as gastric inhibitory peptide) |
GLP1 |
glucagon-like peptide 1 |
T2D |
type 2 diabetes |
GLP1R |
glucagon-like peptide 1 receptor |
GLP1RA |
glucagon-like peptide 1 receptor agonist |
DPP4 |
dipeptidyl peptidase 4 |
DPP4i |
dipeptidyl peptidase 4 inhibitor |
DKD |
diabetic kidney disease |
T1D |
type 1 diabetes |
ESRD |
end stage renal disease |
GRF |
glomerular filtration rate |
KRT |
kidney replacement therapy |
PCSK1 |
proprotein convertase subtilisin-kexin type 1 |
PCSK3 |
proprotein convertase subtilisin-kexin type 3 |
cAMP |
cyclic adenosine monophosphate |
NEP |
neutral endopeptidase (neprilysin) |
Fc |
fragment crystallizable |
XR |
extended release |
SNAC |
sodium N-(8-[2-hydroxybenzoyl]amino) caprylate |
HbA1c
|
haemoglobin A1c
|
CVOT |
cardiovascular outcome trial |
LEADER trial |
the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results trial |
eGFR |
estimated glomerular filtration rate |
SUSTAIN-6 trial |
the Trial to Evaluate Cardiovascular and Other Long-Term Outcomes with Semaglutide in Subjects with Type 2 Diabetes trial |
EXSCEL trial |
the Exenatide Study of Cardiovascular Event Lowering trial |
CARMELINA trial |
the Cardiovascular and Renal Microvascular Outcome Study with Linagliptin trial |
UACR |
urine albumin-to-creatinine ratio |
SAVOR-TIMI 53 trial |
the Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus—Thrombosis in Myocardial Infraction trial |
AGE |
advanced glycation end-product |
AOPP |
advanced oxidation protein product |
NADPH |
reduced form of nicotinamide adenine dinucleotide phosphate |
NF-ĸB |
nuclear factor ĸB |
TGF-β |
transformin growth factor-β |
ERα |
oestrogen receptor α |
ERβ |
oestrogen receptor β |
GLUT4 |
glucose transporter type 4 |
NHE3 |
sodium-hydrogen exchanger 3 |
SDF1α |
stromal cell-derived factor 1α |
ICAM1 |
intercellular adhesion molecule 1 |
TLR2 |
toll-like receptor 2 |
TLR4 |
toll-like receptor 4 |
TNF |
tumour necrosis factor |
IL-1B |
interleukin 1B |
MAPK8 |
mitogen-activated protein kinase 8 |
SOCS3 |
suppressor of cytokine signalling 3 |
CCl2 |
C-C motif chemokine ligand 2 |
NGAL |
neutrophil gelatinase-associated lipocalin |
CRP |
C reactive protein |
IL-6 |
interleukin 6 |
IL-18 |
interleukin 18 |
LDL |
low density lipoprotein |
HDL |
high density lipoprotein |