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. 2021 Nov 2;13(11):2202. doi: 10.3390/v13112202

Figure 5.

Figure 5

Mucosal responses to soluble S-protein or S-TMC NPs in the lungs of immunized mice. Lungs of immunized mice were collected on Day 45 and processed by homogenization. The levels of S- and RBD-specific IgA (A) or IgG (B) antibodies in lung homogenates were detected by indirect ELISA. Binding antibodies against SARS-CoV-2 particles (virion–IgG) of WT (C) and Delta variant viruses (D) present in the lung homogenates diluted at 1:100 was determined by capture ELISA. Data are means ± SD (n = 4); * and # indicate a significant difference between soluble S-protein and S-TMC NPs at 10 and 20 μg/dose, respectively (p < 0.05). Dotted line indicates the LOD of the assay.