Table 1.

Biological activity of peptides analogs of Ahx.

Structure	Antifibrynolytic Activity IC50 [mM]	Antiamidolytic Activity/S-2251 IC50 [mM]	References
EACA	0.2	-	[20]
H-EACA-NLeu-OH	<0.02	0.12	[21,22,23,24,25]
HCl × H-EACA-Leu-OH	0.08	13
HCl × H-EACA-Leu-OEt	-	0.2
HCl × H-EACA-Cys(S-Bzl)-OH	0.04	18
HCl × H-EACA-Cys(S-Bzl)-OEt	-	12
H-EACA-EACA-OMe	-	0.16	[26,27]
HCl × H-EACA-Gly-OH	0.8	8
HCl × H-EACA-Glu-OH	-	0.08
Boc-EACA-Lys(Z)-EACA-NH2	20	20	[28]
Boc-EACA-Lys-EACA-NH2	19	0.02
H-EACA-Lys-EACA-NH2	8.1	9
Boc-EACA-Lys(Z)-EACA-OMe	1.2	>20
H-EACA-Lys-EACA-OMe	18	0.8
Boc-Lys(Z)-EACA-NH2	<0.2	8
Boc-Lys-EACA-NH2	<0.2	-
H-D-Ala-Phe-Lys-EACA-NH2	-	0.02	[29]