Table 2.

Ahx introduction into the structure of peptides with biological activity (the original abbreviations of 6-aminohexanoic acid used in the references were used in the table).

Structure with Ahx	Biological Activity Benefits of Inserting of Ahx	References
Boc-Acp-Aib-Phe-OMe	Peptides form hydrogen bonded dimers that gives supramolecular β-sheets on self-assembly.	[34]
cyklo[Lys-Tyr-Lys-Ahx-] cyklo[Lys-Trp-Lys-Ahx-]	Higher DNA binding constant than linear analog.	[35]
cyclo(L-Ala-L-Ala-Aca) cyclo(L-Ala-D-Ala-Aca)	Cyclization facilitates penetration through the Caco-2 human epithelial cancer cell line monolayer.	[36]
cyclo-[L-Asn-Gly-Aca] cyclo-[Gly-Asn-Aca]	Cyclic peptides assume predominantly β-turn structures in solution, faster deamidation than linear analogs.	[37]
Ahx-SIIIA	Improve bioavailability by reducing susceptibility to proteolysis, and reducing hydrogen bond donors/acceptors.	[38]
Y-(6-Ahx)-Phe-Met	Reduction of affinity and agonist activity towards δ- and μ-opioid receptors, while maintaining strong antinociceptive and anticonvulsant properties.	[39]
(Ahx)2T127FIQFKKDLKEW137(Ahx)2	Improvement of coating efficiency in ELISA immunoassay procedures.	[40]

Acp, Aca = 6-aminocaproic acid; SIIIA—μ-conotoxins—cone snail venom toxin.