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. 2021 Nov 16;22(22):12346. doi: 10.3390/ijms222212346

Figure 3.

Figure 3

The effect of GLP-1R agonists and L-dopa on the motor and L-dopa induced dyskinesia tests. (A) Amphetamine induced rotation test, (B) vibrasae test, (C) stepping test and (D) cylinder test on week 12 post transplantion of rats received either saline, Ex-4 or Lira in −/+ LD groups. The data were expressed as a percentage of the baseline (pre-transplantation time point) in number of ipsilateral rotations, contralateral reflex, contralateral steps and contralateral touches, respectively. (E) AIMs (F) L-dopa induced rotation received either Ex-4, Lira or no GLP-1R agonists in +LD treated groups at pre-trx and week 11 time points. The data were expressed as total number of AIMs or number of contralateral rotations per min, respectively. (a–f) illustration of statistical summary of (A–F) respectively. (A–D,F) two-way ANOVA, (E) Kruskal-Wallis test, * p < 0.05, ** p < 0.01. n = G − LD (7), G + LD (8), G − LD + Ex-4 (9), G + LD + Ex-4 (8), G − LD + Lira (6), G + LD + Lira (7). n.s. = not significant, LD = L-dopa; Ex-4 = Exendin-4; Lira = Liraglutide; Pre-trx = Pre- transplantation.