Table 3.
Interaction between alcohol consumption and ABCG2 rs2231142.
| Variables | Male (n = 41,265) | Female (n = 73,272) | ||
|---|---|---|---|---|
| OR (95% CI) b | p-Value a | OR (95% CI) | p-Value a | |
| Intercept | 0.006 (0.003–0.015) | <0.001 | 0.016 (0.010–0.038) | <0.001 |
| Age 45–55 | 0.851 (0.803–0.901) | <0.001 | 1.031 (0.902–1.178) | <0.001 |
| Age 55–70 | 0.699 (0.665–0.736) | <0.001 | 2.508 (2.251–2.794) | <0.001 |
| Current alcohol consumption | 1.530 (1.443–1.623) | 0.007 | 1.866 (1.530–2.276) | <0.001 |
| BMI | 1.162 (1.155–1.117) | <0.001 | 1.207 (1.198–1.213) | <0.001 |
| Body fat percentage | 1.105 (1.101–1.110) | <0.001 | 1.139 (1.133–1.145) | <0.001 |
| Blood pressure | 1.010 (1.009–1.011) | <0.001 | 1.027 (1.025–1.028) | <0.001 |
| Total cholesterol | 1.004 (1.002–1.006) | 0.001 | 1.006 (1.002–1.009) | 0.001 |
| Triglyceride | 1.002 (1.002–1.003) | <0.001 | 1.002 (1.002–1.003) | <0.001 |
| HDL cholesterol | 0.973 (0.970–0.976) | <0.001 | 0.951 (0.946–0.956) | <0.001 |
| LDL cholesterol | 1.002 (1.000–1.005) | 0.067 | 1.005 (1.001–1.009) | 0.007 |
| Fasting glucose | 0.993 (0.992–0.994) | <0.001 | 1.004 (1.003–1.005) | <0.001 |
| rs2231142 | 1.707 (1.634–2.828) | <0.001 | 2.745 (2.219–2.880) | <0.001 |
| Alcohol consumption ×rs2231142 | 2.183 (2.059–2.315) | <0.001 | 3.096 (2.403–3.988) | 0.001 |
a The odds ratios and p-values are assessed by combining with the interaction of current alcohol consumption. b OR = odds ratio; 95% CI = 95% confidence interval.