Table 9.

Plasma pharmacokinetic parameters of MeP and MeP-loaded NPs. Data are shown as mean ± S.D. (n = 3).

Parameters	Formulations						Units
	MnClTPP	MnClTPP-NPs	CoTPP	CoTPP-NPs	NiTPP	NiTPP-NPs
AUCinf	15,362 ± 5377	9362 ± 3745 *	60,370 ± 18,111	1406 ± 211 *	612 ± 184	1133 ± 453	(µg/mL) * (h)
Vd	0.013 ± 0.004	0.188 ± 0.066 *	0.003 ± 0.001	3.083 ± 0.462 *	2.683 ± 0.805	2.614 ± 0.915	L/kg
t1/2	44 ± 14	37 ± 14 *	17 ± 4	33 ± 5 *	19 ± 6	24 ± 8	h
MRT	62 ± 21	53 ± 21 *	27 ± 7	66 ± 8 *	25 ± 6	45 ± 16	h

* p < 0.05 compared with free MeP.