Figure 6.

Lymphocyte activation assays for the evaluation of the immunomodulatory effect of S-MenSCs and S-MenSCs*. PBLs from healthy donors (n = 3–4, different symbols) were activated and co-cultured with S-MenSCs and S-MenSCs* for 72 h (n = 3, different colors). (a) Percentage of CD4+ cells and (b) percentage of CD8+ T cells with CFSE-low. (c) Percentage of CTLA-4 expression on CD4+ T cells. (d) Percentage of PD-1 expression on CD4+ T cells. Individual values are represented together with the mean. Data were analyzed by paired t-test against activated PBLs as matched controls. A p value was considered significant at * p < 0.05, ** p < 0.05.