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. 2021 Nov 18;22(22):12432. doi: 10.3390/ijms222212432

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of AA treatment on the renal expression of antiaging proteins. (A–C) Relative renal protein expression of Klotho, NAMPT, and SIRT1 in the vehicle-control and AA groups. *** p < 0.001 compared with the vehicle-control group. Data are presented as mean ± SEM (n = 5 per group) and were analyzed using the unpaired Student’s t-test. AA: aristolochic acid; GAPDH: glyceraldehyde-3-phosphate dehydrogenase, NAMPT: nicotinamide phosphoribosyltransferase; NS: nonspecific band; SIRT1: sirtuin1.