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. 2021 Nov 16;11(11):3091. doi: 10.3390/nano11113091

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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In vivo imaging of fluorescent B2M nanoMIPs. (A) Representative images of young (2 months) and old (15 months) mice injected intravenously with Alexa Fluor 647-tagged B2M MIPs. Control mice were injected only with vehicle. Animals were imaged in the prone position 2 h after injection. Total fluorescence signals were quantified and are shown in units of radiant efficiency. (B) Same as (A), with another group of mice of different ages, imaged in supine position. (C) 3D whole-body micro-CT (top) and fluorescence imaging tomography (FLIT, bottom) of the 15-month-old mouse in (A). Reproduced with permission [77] © 2021 The Royal Society of Chemistry.