Figure 3.

Cis-translocation breakpoint distributions in G1-arrested pro-B mouse cells evaluated by the contact-first mechanism. In all panels: experiment [21], simulations for the heteropolymer globule models. (a) Chromosome 18, the probability of contact-exchange P_c-e = 0.0029. For radiation doses of 0 and 5 Gy, Pearson’s correlation between theory and experiment R = 0.898 and R = 0.724, respectively. Following irradiation, the formation of translocations was taken into account both between recurrent and spontaneous, and between recurrent and IR-damaged chromosome subunits. (b) Chromosome 7, D = 5 Gy, P_c-e = 0.0029. (c) Chromosome 2, D = 5 Gy, P_c-e = 0.0035. For chromosomes 2 and 7, the control in [21] is negligible compared to 5 Gy, so it is not shown in the graphs. See Figure S4 for comparison with predictions for alternative models of structure.