Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 10;22(22):12186. doi: 10.3390/ijms222212186

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

The simulated dynamics of lesion contact formation. Left side: The segments of the calculated contact maps including the loci under consideration. The heteropolymer globule model of chromosomes. The numbers above and below are the genomic positions of the segments, Mb. The black lines indicate the positions of I-SceI site. The colored stripes to the right of the map show the genomic separations between the considered loci. Graphs: the examples of dynamics of locus pairs with genomic separations s = 3, 10 and 50 Mb from I-SceI site and at the spatial distance r, r + dr at the initial time. γ-radiation dose D = 5 Gy. (a,b) Chromosome 18; (c,d) chromosome 7; (e,f) chromosome 2. (a,c,e) The number of contacts formed during the time from 0 to t between the damaged loci located at different initial distances between them, in diameter units. (b,d,f) The number of contacts formed as a function of the initial distance between the damaged loci for different observation times t (observation interval from 0 to t).

The simulated dynamics of lesion contact formation. Left side: The segments of the calculated contact maps including the loci under consideration. The heteropolymer globule model of chromosomes. The numbers above and below are the genomic positions of the segments, Mb. The black lines indicate the positions of I-SceI site. The colored stripes to the right of the map show the genomic separations between the considered loci. Graphs: the examples of dynamics of locus pairs with genomic separations s = 3, 10 and 50 Mb from I-SceI site and at the spatial distance r, r + dr at the initial time. γ-radiation dose D = 5 Gy. (a,b) Chromosome 18; (c,d) chromosome 7; (e,f) chromosome 2. (a,c,e) The number of contacts formed during the time from 0 to t between the damaged loci located at different initial distances between them, in diameter units. (b,d,f) The number of contacts formed as a function of the initial distance between the damaged loci for different observation times t (observation interval from 0 to t).