Figure 1.

Illustration of experimental design. Establishment of streptozotocin (STZ)-induced sporadic Alzheimer’s Disease (sAD) mouse model, immunization regimen and experimental procedures are shown. The mice were divided into four groups: STZ 0 plus vehicle; STZ 0 plus mAb; STZ 3 plus vehicle; STZ 3 plus mAb and housed in groups. The dose of 12A12mAb administered to mice in this study was calculated according to [1,39] and administered by intravenous injection into the lateral caudal vein on two alternated days up to 3 weeks.