Figure 8.

Effect of 12A12mAb immunization on synaptic changes of synapsin I and α-synuclein in the hippocampus of ICV-STZ mice. (A,B) Representative images (n = 3) of immunofluorescence analysis (20×) showing the punctate staining of the synapsin I (A) and α-synuclein (B) (red channel) in hippocampal CA2/CA3 regions from animals of four experimental groups (STZ 0 plus vehicle; STZ 0 plus mAb; STZ 3 plus vehicle; STZ 3 plus mAb). Nuclei were counterstained with DAPI (blue channel). Scale bar = 20 µm.