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C1q conjugated CD40L/HIV VLPs (C1q/CD40L/HIV VLPs) induces mucosal immune response. (1) Preferential binding of C1q conjugated CD40L/HIV VLPs to epithelial layer CD91; (2) Preferential binding of C1q conjugated CD40L/HIV VLPs to the oral sub-mucosal DC surface receptor CD91; (3) Additional binding of CD40L to oral sub-mucosal DCs.
