Figure 5.
Effect of blackcurrant on left ventricle (LV) remodeling in type 2 diabetes mellitus mice (T2DM mice). Representative echocardiography images (M-mode) for each group (A). Changes of cardiac function of EF (Ba) and FS (Bb) were measured echocardiography in each group (n = 8 per group). Changes in plasma of the cardiac biomarkers LDH (Ca), CKMB (Cb), and CPK (Cc) (n = 8 per group). EF, ejection fraction; FS, fractional shortening; LDH, lactate dehydrogenase; CKMB, creatine kinase MB isoenzyme; CPK, creatine phosphokinase; Cont, control (db/m mice); T2DM, type 2 diabetes mellitus mice (db/db mice); Vil.G, db/db + vildagliptin 50 mg/kg/day, positive control, dipeptidyl peptidase-4 (DPP-4) inhibitor; Bla.C, db/db + blackcurrant 200 mg/kg/day. Data are shown as mean ± S.E. * p < 0.05 and ** p < 0.01 vs. Cont.; # p < 0.05 vs. T2DM.