Figure 3.

TMA docking to FMO3 could involve different amino acids in mutated enzymes. The non-sense and missense variants carried by mutated FMO3 (a–o) might shift the TMA binding sites far from the wild-type active site of the enzyme (p). The black arrows indicate the TMA (white spheres) bonded to the active site of FMO3, whose aa are represented as ball-and-stick. The other aa, represented as ball-and-stick, separated from the ones in the catalytic site, are the aa involved in mutations.