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. 2021 Nov 22;19(11):650. doi: 10.3390/md19110650

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© 2021 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The 3D graph shows the predicted pharmacological activities of 2-hydroxyestrone (7). 2-Hydroxyestrone (2-OHE1) or 2.3-estracatechol, also known as estra-1,3,5(10)-trien-2,3-diol-17-one, is an endogenous, naturally occurring catechol estrogen that was first isolated from human urine more than 60 years ago [106], apparently as a product of estrone and estradiol metabolism. According to the PASS data, 2-hydroxyestrone is the strongest ovulation inhibitor among aromatic steroids. In addition, it is a cardiovascular analeptic and can be used as a drug for the treatment and prevention of male reproductive dysfunction, menopausal disorders in women, as well as treatment of muscular dystrophy.