Figure 5.

The 3D graph shows the predicted pharmacological activities of estriol 3-glucuronide (6). The water-soluble conjugate of estriol, also known as estriol 3-β-D-glucosiduronic acid, is a naturally occurring steroidal estrogen containing β-D-glucopyranuronic acid that was first discovered and isolated from the urine of women in the late 1930s [107,108,109]. According to the PASS data, estrone glucuronide, in addition to the main antihypercholesterolemic activity (97.3%), is also a potent regulator of lipid metabolism with a reliability of 90.7% and can be used to treat acute neurological disorders (92.2%).