Table 1.
Biological activities of aromatic steroids with over 90% confidence.
| No. | Discovered Activity, (Pa) * | Reported Activity | References |
|---|---|---|---|
| 1 | Ovulation inhibitor (0.942) Cardiovascular analeptic (0.924) Antihypercholesterolemic (0.871) Lipid metabolism regulator (0.730) |
Inhibitor aromatase Sulfatase inhibitor Estrogenic Promotor breast cancer |
[81,82,83,84] |
| 2 | Antihypercholesterolemic (0.904) Ovulation inhibitor (0.889) Neuroprotector (0.870) Anesthetic general (0.868) Acute neurologic disorders treatment (0.793) Prostate disorders treatment (0.729) Anti-inflammatory (0.713) |
Antioxidant Anti-inflammatory Uterotrophic RNA polymerase Promoter of breast, ovarian and endometrial cancers Neuroprotective properties |
[81,85,86,87] |
| 3 | Ovulation inhibitor (0.900) Acute neurologic disorders treatment (0.822) Antihypercholesterolemic (0.791) |
Estrogenic Agonist of the ERs RNA polymerase |
[88,89] |
| 4 | Antihypercholesterolemic (0.856) Ovulation inhibitor (0.847) Cardiovascular analeptic (0.842) Lipid metabolism regulator (0.788) |
Estrogenic Estrogen agonist |
[90,91,92] |
| 5 | Acute neurologic disorders treatment (0.912) Male reproductive disfunction treatment (0.847) Ovulation inhibitor (0.786) Postmenopausal disorders treatment (0.643) Antihypercholesterolemic (0.640) Menopausal disorders treatment (0.579) |
Inhibitor aromatase Sulfatase inhibitor Inhibitor of human breast cancer Concentration Cardiovascular agent Postmenopausal disorders |
[93,94] |
| 6 | Antihypercholesterolemic (0.973) Acute neurologic disorders treatment (0.922) Lipid metabolism regulator (0.907) Antithrombotic (0.714) Ovulation inhibitor (0.662) Dementia treatment (0.616) Hypolipemic (0.613) Male reproductive disfunction treatment (0.587) Menopausal disorders treatment (0.582) |
Estrogenic Ovarian activity Urine production |
[95] |
| 7 | Ovulation inhibitor (0.956) Cardiovascular analeptic (0.927) Antihypercholesterolemic (0.868) Male reproductive disfunction treatment (0.847) Menopausal disorders treatment (0.842) Acute neurologic disorders treatment (0.745) Lipid metabolism regulator (0.701) Menstruation disorders treatment (0.639) Postmenopausal disorders treatment (0.605) Muscular dystrophy treatment (0.601) Contraceptive female (0.570) Anti-infertility, female (0.567) |
Estrogenic Antiestrogenic effects Anticancer |
[96,97,98] |
| 8 | Ovulation inhibitor (0.930) Cardiovascular analeptic (0.925) Antihypercholesterolemic (0.855) Male reproductive disfunction treatment (0.843) Acute neurologic disorders treatment (0.780) Menopausal disorders treatment (0.747) Lipid metabolism regulator (0.601) Muscular dystrophy treatment (0.579) Postmenopausal disorders treatment (0.561) Menstruation disorders treatment (0.533) |
Estrogenic Strongest neuroprotective effect UDP-glucuronosyltransferase Anti-breast cancer |
[99,100,101] |
| 9 | Ovulation inhibitor (0.953) Cardiovascular analeptic (0.928) Antihypercholesterolemic (0.857) Menopausal disorders treatment (0.807) Male reproductive disfunction treatment (0.805) Acute neurologic disorders treatment (0.660) Contraceptive (0.655) Lipid metabolism regulator (0.645) Contraceptive female (0.558) Menstruation disorders treatment (0.542) Anti-infertility, female (0.503) Postmenopausal disorders treatment (0.500) |
Antioxidant Estrogenic Anti-breast cancer |
[102] |
| 10 | Ovulation inhibitor (0.925) Cardiovascular analeptic (0.922) Antihypercholesterolemic (0.833) Male reproductive disfunction treatment (0.821) Menopausal disorders treatment (0.712) Acute neurologic disorders treatment (0.662) Contraceptive (0.602) Lipid metabolism regulator (0.571) Muscular dystrophy treatment (0.548) |
Estrogenic Proliferation of human breast cancer |
[103,104,105] |
| 11 | Antihypercholesterolemic (0.959) Hypolipemic (0.808) |
Activity not studied | |
| 12 | Lipid metabolism regulator (0.913) Antihypercholesterolemic (0.767) |
Activity not studied | |
| 13 | Antihypercholesterolemic (0.961) Hypolipemic (0.711) |
Activity not studied | |
| 14 | Antihypercholesterolemic (0.953) | Activity not studied | |
| 15 | Antihypercholesterolemic (0.946) | Activity not studied | |
| 16 | Antihypercholesterolemic (0.907) | Activity not studied | |
| 17 | Antihypercholesterolemic (0.929) | Activity not studied | |
| 18 | Antihypercholesterolemic (0.935) | Activity not studied | |
| 19 | Antihypercholesterolemic (0.950) | Activity not studied | |
| 20 | Antihypercholesterolemic (0.914) | Anticancer | [52] |
* Only activities with Pa > 0.5 are shown.