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. 2021 Nov 19;10(22):5394. doi: 10.3390/jcm10225394

Table 1.

Correlation between radiologic features and BC subtypes—literature review.

MMG
  • Luminal cancers commonly appear as densities with spicular margins, while TNBC and HER2+ cancer often exhibit blurred margins [2]

  • TNBC subtype (in particular high grade ones, G3) appear as well delineated densities without microcalcifications, and therefore, may imitate benign lesions [3]

US
  • Microlobular margins are more commonly found in TNBC [7]

  • TNBC presented as microlobulated, markedly hypoechoic masses with an abrupt interface [8]

  • High grade (G3) TNBC type more commonly appears as lesions with irregular shape [9]

  • Tumors with HER2 overexpression exhibit higher Young’s modulus values in shear wave elastography (SWE) than LA tumors [10]

  • Similar, high Young’s modulus values in SWE for all molecular BC subtypes, with the exception of tubular BC [11]

  • Particular sets of features for individual breast cancer types [12]

MR
  • MRI reveals stronger background parenchymal enhancement (BPE) in TNBC, weaker in luminal B (HER2−) type [4]

  • TNBC subtype usually appears as unifocal necrotic masses with heterogeneous marginal enhancement and increased signal intensity in T2-weighted images, which corresponds to necrosis [6]

MMG = mammography, US = ultrasound scan, MRI = magnetic resonance; LA = luminal A; LB HER2− = luminal B without HER2 overexpression; LB HER2+ = luminal B with HER2 overexpression; HER2+ = human epidermal growth factor receptor 2 positive; TNBC = triple negative breast cancer.