Table 3.
Biomaterial | Effects | Bioprinting Method * | References |
---|---|---|---|
Alginate | Increased BGLAP, COL1A1, SPP1 expression, round morphology, stiffness may encourage osteoblast differentiation, stemness preservation, low viability | Inkjet | [91,93,94] |
Collagen | Osteogenic genes are upregulated with inhibition of TNF-α, enhanced in vivo bone regeneration, multipolar or bipolar morphology | - | [98,99,100] |
Gelatin | Good cell proliferation and adhesion, ossification in vivo, enhance osteogenesis, early upregulation of OPN and RUNX2 | - | [101,102,103,104] |
Hyaluronic Acid | Can cause osteogenic, chondrogenic, or adipogenic differentiation, mineralized matrix formation and calcium deposition, long term cell preservation | - | [105,106,107] |
Alginate/Collagen | High viability and cell proliferation | Custom | [108] |
Collagen/Hyaluronic Acid | Strong cell proliferation, associated with chondrogenesis, greater hyaluronic concentration inhibits chondrogenesis | - | [109,110] |
* If applicable.