Table 4.
Biomaterial | Effects | Bioprinting Method * | References |
---|---|---|---|
Alginate | Early osteogenic nodule formation, poor diffusion of differentiation factors/dyes, spherical morphology, lower cell viability, presence of calcium deposition | Extrusion | [91,111,112] |
Collagen | Can induce osteogenic differentiation, mineralization present by 21 days, RUNX2 upregulation, cells bind to integrin proteins | - | [114,115,116] |
Gelatin | Cytoprotective function, osteogenesis and chondrogenesis, strong proliferation and cell viability | - | [117,118] |
Hyaluronic Acid | Increase in osteogenic markers, blood vessel formation and mineralization in vivo, early bone formation | - | [120,121] |
Alginate/Collagen | Lower cell viability but persistent cell proliferation, survival depends on alginate/collagen concentrations, greater BSP, OCN, and OPN expression | - | [122] |
Collagen/Hyaluronic Acid | Early chondrogenesis, upregulation of SOX9 and collagen type II, greater cell migration | - | [123] |
* If applicable.