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. 2021 Nov 10;21(22):7477. doi: 10.3390/s21227477

Table 4.

Bone marrow stem cells in scaffolds.

Biomaterial Effects Bioprinting Method * References
Alginate Early osteogenic nodule formation, poor diffusion of differentiation factors/dyes, spherical morphology, lower cell viability, presence of calcium deposition Extrusion [91,111,112]
Collagen Can induce osteogenic differentiation, mineralization present by 21 days, RUNX2 upregulation, cells bind to integrin proteins - [114,115,116]
Gelatin Cytoprotective function, osteogenesis and chondrogenesis, strong proliferation and cell viability - [117,118]
Hyaluronic Acid Increase in osteogenic markers, blood vessel formation and mineralization in vivo, early bone formation - [120,121]
Alginate/Collagen Lower cell viability but persistent cell proliferation, survival depends on alginate/collagen concentrations, greater BSP, OCN, and OPN expression - [122]
Collagen/Hyaluronic Acid Early chondrogenesis, upregulation of SOX9 and collagen type II, greater cell migration - [123]

* If applicable.